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Delayed Effect and Receptor Binding

Most of the ICP modules relate dose to plasma drug concentration. However, in practice, the relationship between dose and drug effect is more important to the patient and healthcare provider. All drugs have a delay of effect in relation to plasma concentration. For some drugs there is a delay in effect as the drug occupies its target receptor. This delay is due to dissociation (“elimination”) from the receptor.

Move the slider to see the relationships between Cp, rate of drug-receptor dissociation and drug effect as the drug dissociates from the receptor with different half-lives.

Cp (mg/L)

Receptor Binding



Time (hrs)

Rapid Slow