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Human Efflux Model

P-glycoprotein (P-gp) is an active transporter that protects the body from some harmful substances (including some drugs) by transporting the substance out of the body or out of sensitive organs. Examples:

  1. It transports drugs back out of the gut wall into the gut lumen, thus reducing absorption!
  2. It helps keep some drugs out of the brain.
  3. It transports drugs out of the kidney into the urine. Some drugs inhibit P-glycoprotein, allowing more of the first drug to be absorbed and less to be excreted, and allowing more of the drug to reach organs such as the brain.
Select the bodypart: Gut Brain Kidneys
Gut Animation Zoomed Gut Animation Zoomed Gut Animation Zoomed Gut Animation Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow Gut Arrow
Brain Animation Brain Arrows Brain Arrows
Brain Animation Kidneys Arrow Kidneys Arrow

Stomach

Small Intestine

P-glycoprotein

P-glycoprotein

Diffusion

Brain

P-glycoprotein

Diffusion

Kidney

P-glycoprotein

Give drug: