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Pharmacogenetics

Pharmacogenetics

Sometimes people have different drug clearances because their genetics (genotypes) differ.

Each genotype has a phenotype (e.g. enzyme activity) that has its own normal distribution.The different normal distributions are termed polymorphisms.

NB: The 'normal' status is the EM, which is sometimes called the 'wild type'.

Toggle the genetic status buttons to see how that affects drug concentrations.

Pharmacogenetics Background
IM Animation
EM Animation
PM Animation
UM Animation
EM Alleles IM Alleles PM Alleles UM Alleles

- wild type allele

- mutant allele

Chromosome

Alleles

Population (%)

Time

Concentration

Min toxic conc

Min effective conc

PM

IM

EM

UM

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Genetic status: