Oral availability defines how much drug gets 'on board' after oral ingestion. It is determined by 'absorption' and 'first pass' metabolism.
Oral availability is usually defined by comparing the fraction (F) of drug that gets into the body after oral (po) versus IV administration.
The total amount of drug in the systemic circulation is defined by the area under the concentration-time curve (AUC).
Adjust the slider to see how oral availability (F) influences the AUC of orally administered drug.
First Pass Metabolism
Log Cp (mg/L)