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Drug Elimination

Dose Adjustment

Drugs are eliminated by excretion unchanged through the kidneys, or by metabolism to an inactive product usually in the liver.

The fraction excreted unchanged (fe) defines the renal elimination, while (1-fe) describes the metabolic elimination.

Adjust the fe using the slider to see the relative contribution of renal and hepatic elimination.

0

Cp mg/L

minimum toxic concentration

minimum effective concentration

time

0 1.0
poor normal
poor normal
low high