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Drug Elimination

Dose Adjustment

In the event of a change in clearance, the dose rate should be adjusted to the body's elimination capacity.

Adjust the dose rate and observe the influence of a change in renal or liver clearance on the blood concentration of the drug.

Reminder: Dose rate = CL * Cp


Cp mg/L

minimum toxic concentration

minimum effective concentration


0 1.0
poor normal
poor normal
low high