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Drug Elimination

Where?

Altered liver and kidney function may affect drug clearance. For drugs with high fe, renal impairment will decrease the CL. Liver impairment will not affect CL of these drugs.

For drugs with low fe, liver impairment will affect CL, but renal impairment will not.

Adjust the fe and the function of the liver and kidneys to see what happens to drug clearance.

100%

0%

Hepatic Elimination

Renal Elimination

Liver

Kidneys

Bladder

0 1.0