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Ajuste de dose com a idade

Because dose rate = Cpss x CL, the dose rate should be appropriate to the age of the patient.

Adjust age to see what happens to plasma concentration, as determined by clearance.

Then adjust the dose rate to keep the drug concentrations within the therapeutic window.

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Cp mg/L

concentração tóxica mínima

concentração eficaz mínima

tempo

12 yrs 100 yrs
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